Citation
Li, Jiaming (2020) Concise Total Syntheses of ∆¹²-Prostaglandin J Natural Products Using Stereoretentive Metathesis. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/Q78K-7R18. https://resolver.caltech.edu/CaltechTHESIS:11202019-023320724
Abstract
∆¹²-Prostaglandin J family is a type of secondary metabolite isolated in cell culture, and is recently discovered to have potent anticancer activity. Concise syntheses of four ∆¹²-prostaglandin J natural products (7–8 steps in the longest linear sequences) are developed, enabled by convergent stereoretentive cross-metathesis by Ru-based metathesis catalyst. Exceptional control of alkene geometry was achieved through stereoretention.
| Item Type: | Thesis (Dissertation (Ph.D.)) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Subject Keywords: | Natural Product; Total Synthesis; Olefin Metathesis | |||||||||
| Degree Grantor: | California Institute of Technology | |||||||||
| Division: | Chemistry and Chemical Engineering | |||||||||
| Major Option: | Chemistry | |||||||||
| Thesis Availability: | Public (worldwide access) | |||||||||
| Research Advisor(s): |
| |||||||||
| Thesis Committee: |
| |||||||||
| Defense Date: | 18 November 2019 | |||||||||
| Record Number: | CaltechTHESIS:11202019-023320724 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechTHESIS:11202019-023320724 | |||||||||
| DOI: | 10.7907/Q78K-7R18 | |||||||||
| Related URLs: |
| |||||||||
| ORCID: |
| |||||||||
| Default Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 13581 | |||||||||
| Collection: | CaltechTHESIS | |||||||||
| Deposited By: | Jiaming Li | |||||||||
| Deposited On: | 04 Dec 2019 18:39 | |||||||||
| Last Modified: | 08 Nov 2023 00:39 |
Thesis Files
|
PDF
- Final Version
See Usage Policy. 13MB |
Repository Staff Only: item control page
