Published September 1, 2004
| Published
Journal Article
Open
Spectral triangulation molecular contrast optical coherence tomography with indocyanine green as the contrast agent
Chicago
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Abstract
We report a new molecular contrast optical coherence tomography (MCOCT) implementation that profiles the contrast agent distribution in a sample by measuring the agent's spectral differential absorption. The method, spectra triangulation MCOCT, can effectively suppress contributions from spectrally dependent scatterings from the sample without a priori knowledge of the scattering properties. We demonstrate molecular imaging with this new MCOCT modality by mapping the distribution of indocyanine green, a FDA-approved infrared red dye, within a stage 54 Xenopus laevis.
Additional Information
© 2004 Optical Society of America. Received April 2, 2004. We thank several colleagues for suggesting the use of ICG as a MCOCT contrast agent, most notably Hubert van den Bergh. This research was supported by National Institutes of Health grant EB000243.Attached Files
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Additional details
- PMCID
- PMC1283115
- Eprint ID
- 2806
- Resolver ID
- CaltechAUTHORS:YANol04
- NIH
- EB000243
- Created
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2006-04-28Created from EPrint's datestamp field
- Updated
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2020-03-09Created from EPrint's last_modified field