Published October 15, 2000
| Published
Journal Article
Open
Interferometric phase-dispersion microscopy
Chicago
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Abstract
We describe a new scanning microscopy technique, phase-dispersion microscopy (PDM). The technique is based on measuring the phase difference between the fundamental and the second-harmonic light in a novel interferometer. PDM is highly sensitive to subtle refractive-index differences that are due to dispersion (differential optical path sensitivity, 5 nm). We apply PDM to measure minute amounts of DNA in solution and to study biological tissue sections. We demonstrate that PDM performs better than conventional phase-contrast microscopy in imaging dispersive and weakly scattering samples.
Additional Information
© 2000 Optical Society of America Received July 20, 2000 This work was carried out at the Laser Biomedical Research Center of the Massachusetts Institute of Technology and was by supported by National Institutes of Health (NIH) grant P41-RR02594, National Science Foundation grant 9708265-CHE, and a grant from Hamamatsu Corporation. Adam Wax and Irene Georgakoudi were supported by NIH National Research Service Awards 1 F32 RR05075-01 and 1 F32 CA80345-01, respectively.Attached Files
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Additional details
- Eprint ID
- 3328
- Resolver ID
- CaltechAUTHORS:YANol00
- NIH
- P41-RR02594-18
- NSF
- CHE-9708265
- Hamamatsu Corporation
- NIH Postdoctoral Fellowship
- 1 F32 RR05075-01
- NIH Postdoctoral Fellowship
- 1 F32 CA80345-01
- Created
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2006-05-30Created from EPrint's datestamp field
- Updated
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2020-03-09Created from EPrint's last_modified field