Published June 1945
| Published
Journal Article
Open
Studies on the denaturation of antibody: II. The effect of protein concentration on the rate of denaturation of diphtheria antitoxin by urea
- Creators
- Wright, George G.
Abstract
The specific rate of inactivation of antitoxin in urea solutions, as measured by the Römer neutralization test with toxin, has been shown to be independent of the concentration of protein under the conditions studied. The amount of precipitate obtained in the quantitative precipitation test with toxin, however, increases greatly with increasing protein concentration during denaturation. The time during which the protein concentration is important in this respect has been shown to be the interval in which the urea is being dialyzed from the solutions. The meaning of the results is discussed.
Additional Information
© 1945, by The Rockefeller Institute for Medical Research New York. (Received for publication, April 2, 1945) This investigation was carried out with the aid of a grant from The Rockefeller Foundation. The author is indebted to Professor Linus Pauling, Dr. Verner Schomaker, Dr. Dan H. Campbell, and other associates for suggestions and discussion. Contribution No. 1004 fFrom the Gates and Crellin Laboratories of Chemistry, California Institute of Technology, PasadenaAttached Files
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Additional details
- PMCID
- PMC2135519
- Eprint ID
- 4415
- Resolver ID
- CaltechAUTHORS:WRIjem45
- Rockefeller Foundation
- Created
-
2006-08-22Created from EPrint's datestamp field
- Updated
-
2021-11-08Created from EPrint's last_modified field
- Other Numbering System Name
- Gates and Crellin Laboratories of Chemistry
- Other Numbering System Identifier
- 1004