Published March 1985
| public
Journal Article
Interactions of synthetic polymers with cell membranes and model membrane systems. Part 6. Disruption of phospholipid packing by branched poly(ethylenimine) derivatives
- Creators
- Takigawa, Doreen Y.
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Tirrell, David A.
Abstract
High-sensitivity differential scanning calorimetry was used to examine the phase transition behavior of mixtures of dipalmitoylphosphatidylcholine (DPPC) or dipalmitoylphosphatidylglycerol (DPPG) with linear or branched poly(ethylenimine) derivatives. Unmodified poly(ethylenimines), branched or linear, caused no observable change in the melting of DPPC. Both polymers broadened the DPPG melting endotherm and produced small changes in the melting temperature. Attachment of side chains 6-12 carbon atoms in length produced hydrophobic poly(ethylenimine) derivatives which bound strongly to DPPC with complete disruption of the multilamellar vesicle structure.
Additional Information
© 1985 American Chemical Society. Received May 18, 1984. Part 6 in a series on Interactions of Synthetic Polymers with Cell Membranes and Model Membrane Systems. This work was supported by 3M, St. Paul, MN. D.A.T. acknowledges the support of the Alfred P. Sloan Foundation (for a research fellowship) and of Dr. Thomas T. Chiu of Dow Chemical Co. [for a gift of poly(2-ethyloxazoline)]. NMR spectra were recorded on a Bruker WM-300 spectrometer purchased with the aid of a grant from the National Institutes of Health (GM27390-01). The purchase of the calorimeter was assisted by the National Science Foundation (CHE 79-11206). Registry No. DPPC, 63-89-8: dipalmitoylphosphatidylglycerol, 4537-77-3.Additional details
- Eprint ID
- 53646
- Resolver ID
- CaltechAUTHORS:TAKm1985
- 3M
- Alfred P. Sloan Foundation
- GM27390-01
- NIH
- CHE 79-11206
- NSF
- Created
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2015-01-20Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field