The incorporation of amino acids into ribonucleic acid
Abstract
The incorporation of radioactive leucine, valine, and glycine into the ribonucleic acid (RNA) of a soluble enzyme fraction of rat liver has recently been reported by Hoagland et al.(1) Ogata and Nohara(2) have studied the incorporation of alanine into RNA. The former authors consider this incorporation to be an intermediate stage in the transfer of labeled amino acids into microsomal protein. This paper describes the fractionation of the crude system for amino acid incorporation into RNA into an activating enzyme fraction and RNA. Both these components are required for incorporation, thus providing a biological assay for functional RNA. Evidence is presented that a specific activating enzyme and a specific RNA are involved in the incorporation of each amino acid.
Additional Information
© 1958 by the National Academy of Sciences. Communicated by James Bonner, December 12, 1957. The authors wish to acknowledge the excellent technical assistance of Mr. Kenneth Fleshman. [R.S.S.] [e]stablished investigator of the American Heart Association. These studies were supported by a grant from the National Science Foundation. [F.C.B. was a] National Science Foundation Postdoctoral Fellow, summer, 1957.Files
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Additional details
- Eprint ID
- 9571
- Resolver ID
- CaltechAUTHORS:SCHWpnas58a
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2008-02-05Created from EPrint's datestamp field
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2019-10-03Created from EPrint's last_modified field