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Published June 1968 | Published
Journal Article Open

Evidence for multiple structural genes for the γ chain of human fetal hemoglobin

Schroeder, W. A.
Huisman, T. H. J.
Shelton, J. Roger
Shelton, Joan Balog
Kleihauer, Enno F.
Dozy, Andrée M.
Robberson, Barbara
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Abstract

A sequence with a specific residue at each position was proposed for the γ chain of human fetal hemoglobin by Schroeder et al. (1) after a study in which hemoglobin from a number of individual infants was used. We have now examined in part the fetal hemoglobin components of 17 additional infants and have observed that position 136 of the γ chain may be occupied not only by a glycyl residue, as previously reported, but also by an alanyl residue.

Additional Information

© 1968 by the National Academy of Sciences. Communicated by Ray D. Owen, April 5, 1968. We appreciate the helpful discussions on genetics with Drs. E.B. Lewis and Ray D. Owen. Dr. Audrey Brown (Department of Pediatrics, Medical College of Georgia) assisted us in obtaining additional samples from babies D.P., W.B., and C.W. We are also indebted to Dr. Edgar Ahern (Department of Pathology, University College Hospital, Jamaica, W.I.) who made samples from baby J. B. available to us. Mr. Gerald Apell assisted in some of the experimental work. This investigation was supported in part by grants (HE-02558 and HE-05168) from the National Institutes of Health, U.S. Public Health Service. E.F.K. was supported by USPHS grant 1 FOS-TW-1127-01 as an International Research Fellow on leave from the Department of Pediatrics, University of Munich, Germany. Division of Chemistry and Chemical Engineering, Contribution no. 3668.

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