The effect of helper virus on Abelson virus-induced transformation of lymphoid cells

Creators: Rosenberg, Naomi; Baltimore, David

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Abstract

Abelson murine leukemia virus (A-MuLV)-transformed fibroblast nonproducer cells were used to prepare A-MuLV stocks containing a number of different helper viruses. The oncogenicity of the A-MuLV stocks was tested by animal inoculation and their ability to transform normal mouse bone marrow cells was measured in vitro. All of the A-MuLV stocks transformed fibroblast cells efficiently. However, only A-MuLV stocks prepared with helper viruses that are highly oncogenic were efficient in vivo and in vitro in hematopoietic cell transformation. In addition, inefficient helpers did not establish a stable infection in lymphoid nonproducer cells. Thus, helper virus has a more central role in lymphoid cell transformation than in fibroblast cell transformation.

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© 1978 by Rockefeller University Press. eginning six months after publication, RUP grants the public the non-exclusive right to copy, distribute, or display the Work under a Creative Commons Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/ and http://creativecommons.org/licenses/by-nc-sa/3.0/legalcode. Received for publication 9 November 1977. We thank Daniel Clark for excellent technical assistance. Supported by grant no. VC-41 from the American Cancer Society and grant no. CA-14051 from the National Cancer Institute. [N.R. was a] Postdoctoral fellow of the American Cancer Society, Massachusetts Division. [D.B. was an] American Cancer Society Professor of Microbiology.

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