Published August 1, 1985
| Published
Journal Article
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Self-degradation of heat shock proteins
Abstract
The 70-kDa heat shock protein of Drosophila decays in vivo at a much faster rate than other abundantly labeled proteins. Degradation also occurs in vitro, even during electrophoresis. It appears that this degradation is not mediated by a general protease and that the 70-kDa heat shock protein has a slow proteolytic action upon itself. Heat-induced proteins in CHO cells and a mouse cell line also degrade spontaneously in vitro, as do certain non-heat shock proteins from Drosophila tissues as well as the cell lines.
Additional Information
© 1985 by the National Academy of Sciences. Communicated by Norman H. Horowitz, April 9, 1985. This work was supported by Public Health Service Grants GM25966B-06, GM33602, and HD-191-60 and a Biomedical Research Support Grant. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.Attached Files
Published - MITpnas85.pdf
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MITpnas85.pdf
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Additional details
- PMCID
- PMC390479
- Eprint ID
- 7446
- Resolver ID
- CaltechAUTHORS:MITpnas85
- GM25966B-06
- NIH
- GM33602
- BIH
- HD-191-60
- NIH
- Created
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2007-02-21Created from EPrint's datestamp field
- Updated
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2021-11-08Created from EPrint's last_modified field