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Published March 28, 2006 | Supplemental Material + Published + Cover Image
Journal Article Open

2-Diazoacetoacetic acid, an efficient and convenient reagent for the synthesis of alpha-diazo-beta-ketoesters

Abstract

The formation of various alpha-diazo acetoacetic esters can be obtained in a single transformation with good to excellent yields using readily available 2-diazoacetoacetic acid.

Additional Information

© The Royal Society of Chemistry 2006 Received (in Bloomington, IN, USA) 13th December 2005, Accepted 27th January 2006. First published on the web 15th February 2006 The authors gratefully acknowledge the NSF (predoctoral fellowship for E.M.F.), Bristol-Myers Squibb (Graduate Fellowship in Synthetic Organic Chemistry to E.M.F.), AstraZeneca, Boehringer Ingelheim, Johnson & Johnson, Pfizer, Merck, Amgen, Research Corporation, Roche, the Dreyfus Foundation, and GlaxoSmithKline for generous funding. Electronic supplementary information (ESI) available: experimental details and characterization data for all compounds. See DOI: 10.1039/b517719g

Attached Files

Published - MEYcc06.pdf

Supplemental Material - MEYcc05supp.pdf

Cover Image - MEYcc06diag.gif

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Created:
August 22, 2023
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October 16, 2023