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Published May 22, 2000 | public
Journal Article Open

Femtonewton Force Spectroscopy of Single Extended DNA Molecules

Abstract

We studied the thermal fluctuations of single DNA molecules with a novel optical tweezer based force spectroscopy technique. This technique combines femtonewton sensitivity with millisecond time resolution, surpassing the sensitivity of previous force measurements in aqueous solution with comparable bandwidth by a hundredfold. Our data resolve long-standing questions concerning internal hydrodynamics of the polymer and anisotropy in the molecular relaxation times and friction coefficients. The dynamics at high extension show interesting nonlinear behavior.

Additional Information

©2000 The American Physical Society Received 27 December 1999 This work was supported by the National Science Foundation CAREER program.

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