Published December 1, 1979
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Journal Article
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Human heterozygosity: A new estimate
Chicago
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Abstract
Several hundred polypeptides from four human diploid fibroblast cell lines were compared by high-resolution two-dimensional polyacrylamide gel electrophoresis and double-label autoradiography under conditions where allelic products that differ by a single charged amino acid would be distinguished. The average heterozygosity represented by this set of gene products appears to be less than 1% for changes involving charged amino acids.
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© 1979 by the National Academy of Sciences. Communicated by Frank H. Ruddle, September 4, 1979. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.Files
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