Published October 1, 1977
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Journal Article
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Gene-Sized DNA Molecules of the Oxytricha Macronucleus have the Same Terminal Sequence
- Creators
- Lawn, Richard M.
Chicago
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Abstract
The DNA in the macronucleus of the ciliated protozoan Oxytricha exists as small linear molecules with a number average size of about 3000 base pairs. Most, and possibly all, of these DNA molecules contain the same inverted terminal repeat sequence of approximately 26 base pairs. In addition to its terminal location, two inverted copies of this same sequence surround single-strand interruptions within these DNA molecules. This sequence arrangement may function in the processing of these molecules from large chromosomal precursors or in the subsequent replication of these small linear DNAs during cell reproduction.
Additional Information
Copyright © 1977 by the National Academy of Sciences Communicated by David M. Prescott, August 2, 1977 I thank David Prescott for his support of this research and assistance in preparing this manuscript, and Glenn Herrick and Ronald Wesley for communication of unpublished results. I also thank Tom Maniatis for assistance in learning the DNA sequencing techniques. This work was supported by National Institutes of Health Grant GM19199 to D. Prescott. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U. S. C. §1734 solely to indicate this fact.Files
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- 6827
- Resolver ID
- CaltechAUTHORS:LAWpnas77
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2006-12-23Created from EPrint's datestamp field
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