Published September 1969
| Published
Journal Article
Open
The process of infection with bacteriophage phiX174, XXX. Replication of double-stranded phiX DNA
Chicago
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Abstract
Intermediates involved in the replication of double-stranded phiX174 RF DNA have been identified and partially characterized. Analysis of pulse-labeled RF DNA suggests that the synthesis of progeny RF molecules involves, in part, the addition of nucleotides to linear complementary strands on a circular parental strand as template, so as to produce intermediate DNA strands of greater than viral length. Electron microscopy reveals DNA rings with "tails" and "double rings," which could be the intermediate structures. A model is postulated for the replication process.
Additional Information
© 1969 by the National Academy of Sciences. Communicated June 30, 1969. This research was supported in part by grant GM 13554 from the U.S. Public Health Service.Attached Files
Published - KNIpnas69.pdf
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KNIpnas69.pdf
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Additional details
- PMCID
- PMC286158
- Eprint ID
- 9061
- Resolver ID
- CaltechAUTHORS:KNIpnas69
- U.S. Public Health Service (USPHS)
- GM 13554
- Created
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2007-10-25Created from EPrint's datestamp field
- Updated
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2019-10-02Created from EPrint's last_modified field