Published September 1, 1971
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A Novel Closed-Circular Mitochondrial DNA with Properties of a Replicating Intermediate
Chicago
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Abstract
A fraction of the covalently closed mitochondrial DNA in mouse L cells contains a replicated heavy-strand segment that is hydrogen bonded to the circular light strand. The inserted single strand is dissociable from the circular duplex at an elevated temperature.
Additional Information
Copyright © 1971 by the National Academy of Sciences Contributed by Jerome Vinograd, June 18, 1971 We gratefully acknowledge the valued assistance of M. Teplitz and J. Edens and the gifts of SV40[22P] DNA and T7[14C]DNA from C.J.B. Tibbetts and L.I. Grossman, respectively. This investigation was supported by USPHS grants CA08014 from the National Cancer Institute and GM15327, GM00086, and GM10991 from the National Institute of General Medical Sciences. H.K. is the recipient of a postdoctoral fellowship from the Helen Hay Whitney Foundation. This is contribution no. 4264 from the Division of Chemistry and Chemical Engineering.Files
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