Transcriptional network underlying Caenorhabditis elegans vulval development
Abstract
The vulval development of Caenorhabditis elegans provides an opportunity to investigate genetic networks that control gene expression during organogenesis. During the fourth larval stage (L4), seven vulval cell types are produced, each of which executes a distinct gene expression program. We analyze how the expression of cell-type-specific genes is regulated. Ras and Writ signaling pathways play major roles in generating the spatial pattern of cell types and regulate gene expression through a network of transcription factors. One transcription factor (lin-29) primarily controls the temporal expression pattern. Other transcription factors (lin-11, cog-1, and egl-38) act in combination to control cell-type-specific gene expression. The complexity of the network arises in part because of the dynamic nature of gene expression, in part because of the presence of seven cell types, and also because there are multiple regulatory paths for gene expression within each cell type.
Additional Information
© 2005 by the National Academy of Sciences. Edited by Eric H. Davidson, California Institute of Technology, Pasadena, CA, and approved February 1, 2005 (received for review November 11, 2004). We thank A. Fire (Stanford University, Stanford, CA) for providing GFP vectors, and I. Hope (University of Leeds, Leeds, U.K.) for providing the C55C3.5::gfp construct. We thank Ryan Baugh, Jennifer Sanders, Mihoko Kato, Steven Kuntz, Alok Saldanha, and reviewers for comments on the manuscript. We thank the Caenorhabditis Genetics Center (University of Minnesota, Minneapolis) for C. elegans strains. T.I. was supported by fellowship DRG-1646 from the Damon Runyon Cancer Research Foundation. Research was supported by the Howard Hughes Medical Institute, with which P.W.S. is an investigator. This paper was submitted directly (Track II) to the PNAS office.Attached Files
Published - INOpnas05.pdf
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Additional details
- PMCID
- PMC555976
- Eprint ID
- 1165
- Resolver ID
- CaltechAUTHORS:INOpnas05
- Damon Runyon Cancer Research Foundation
- DRG-1646
- Howard Hughes Medical Institute (HHMI)
- Created
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2005-12-29Created from EPrint's datestamp field
- Updated
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2023-06-01Created from EPrint's last_modified field