Requirement of Protein Synthesis for Bacteriophage {varphi}X174 Superinfection Exclusion

Abstract

Within 5 to 10 min at 37 C, bacteria infected by bacteriophage {varphi}X174 acquire the ability to exclude superinfecting {varphi}X particles from reproducing themselves. The superinfecting phage are blocked at a stage prior to synthesis of the parental replicative form molecule; the superinfecting deoxyribonucleic acid remains as intact (infective) single strands. Establishment of superinfection exclusion and its maintenance require protein synthesis.

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