Histone-bound RNA, a component of native nucleohistone
- Creators
- Huang, Ru-Chih C.
- Bonner, James
Abstract
We have found that native histone molecules as they occur in the nucleohistone component of pea bud chromatin contain RNA molecules chemically linked to them. The histone-bound RNA constitutes a new class of RNA, differing from other classes in base composition and in chain length. That the RNA content of native histone has not been discovered heretofore is due to the fact that histones are commonly extracted from chromatin with acid, a condition under which the RNA-histone bond is cleaved. Since the nucleohistone component of chromatin is inactive in the support of DNA-dependent RNA synthesis and since the histones are one class of agents responsible for such repression, their association with a specific class of RNA is relevant to considerations of the control of genetic activity.
Additional Information
© 1965 by the National Academy of Sciences. Communicated July 27, 1965. We gratefully acknowledge the counsel and support of our colleagues Professors Norman Davidson and Jerome Vinograd, Drs. Roger Chalkley and Keiji Marushige, and Baldomero Olivera. We appreciate the counsel of Professor Robert Holley in connection with the identification of dihydrouridylic acid. We acknowledge with pleasure also the skillful assistance of Georgia Lau and Ludia Brown. Report of work supported in part by the Herman Frasch Foundation, and by the U.S. Public Health Service, grants GM-5143, GM-3977, and AM-3102.Files
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Additional details
- Eprint ID
- 7782
- Resolver ID
- CaltechAUTHORS:HUApnas65
- Created
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2007-07-19Created from EPrint's datestamp field
- Updated
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2019-10-02Created from EPrint's last_modified field