Published February 1976
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Journal Article
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5'-terminal structure of poliovirus polyribosomal RNA is pUp
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Abstract
Poliovirus RNA purified from virus-specific polyribosomes does not contain m7G in a 5'-5'-pyrophosphate linkage at its 5'-end. The only potential 5'-end found in ribonuclease digests of this RNA is pUp, which is present in a yield of 1 mole/mole of poliovirus RNA. We conclude that a 5'-terminal m7G is not required for translation of at least one RNA species in animal cells.
Additional Information
© 1976 by the National Academy of Sciences. Contributed by David Baltimore, November 10, 1975. This work was supported by Grants #AI08388, CA 12174, and CA 14051 from the National Institutes of Health. M.J.H. is a Postdoctoral Fellow of the American Cancer Society. J.K.R. is a Postdoctoral Fellow of the National Cystic Fibrosis Research Foundation. D.B. is a Research Professor of the American Cancer Society.Files
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