Published September 1, 1949
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Journal Article
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Evidence for a tryptophane cycle in Neurospora
- Creators
- Haskins, Francis A.
- Mitchell, Herschel K.
Chicago
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Abstract
The work of Snell(1) on lactic acid bacteria provided the first evidence that anthranilic acid may act as a precursor to tryptophane in vivo. Since the strains of bacteria which utilize anthranilic acid in the place of tryptophane also use indole, it was not possible to establish the order in which these two precursors occurred. In 1943 Tatum, Bonner and Beadle(2) found that anthranilic acid was accumulated in the culture medium by a Neurospora crassa mutant, strain 10575, which required either tryptophane or indole for growth. It was therefore indicated that anthranilic acid is a precursor to indole in Neurospora.
Additional Information
© 1949 by the National Academy of Sciences. Communicated by G. W. Beadle, July 15, 1949. This work was supported by funds from the Rockefeller Foundation and by funds from the Atomic Energy Commission administered through contract with the Office of Naval Research, United States Navy, Contract N6 onr-244 Task order V.Files
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- CaltechAUTHORS:HASpnas49
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