Published August 1976
| public
Journal Article
Open
Size of murine RNA tumor virus-specific nuclear RNA molecules
- Creators
- Haseltine, William A.
-
Baltimore, David
Chicago
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Abstract
About 1% of the total RNA of cell lines producing murine leukemia virus is virus-specific RNA. About one-third of the virus-specific RNA is located within the nucleus. The size distribution of virus-specific RNA was determined before and after denaturation. Before denaturation, virus-specific RNA sequences sedimented as a heterogeneous population of RNA molecules, some of which sedimented very rapidly. After denaturation, most of the virus-specific RNA had a sedimentation coefficient of 35S or lower, but a small fraction of the nuclear virus-specific RNA sedimented more rapidly than 35S RNA even after denaturation.
Additional Information
Copyright © 1976 by the American Society for Microbiology. Received for publication 25 February 1976 We thank Deborah Spector and Martinez Hewlett for the gift of poliovirus RNA and Robert Weinberg for helpful discussions. This work was supported by grants from the American Cancer Society and the National Cancer Institute. W. H. is a postdoctoral fellow of the Helen Hay Whitney Foundation. D. B. is an American Cancer Society Research Professor.Files
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