Ror receptor tyrosine kinases: orphans no more
Abstract
Receptor tyrosine kinase-like orphan receptor (Ror) proteins are a conserved family of tyrosine kinase receptors that function in developmental processes including skeletal and neuronal development, cell movement and cell polarity. Although Ror proteins were originally named because the associated ligand and signaling pathway were unknown, recent studies in multiple species have now established that Ror proteins are Wnt receptors. Depending on the cellular context, Ror proteins can either activate or repress transcription of Wnt target genes and can modulate Wnt signaling by sequestering Wnt ligands. New evidence implicates Ror proteins in planar cell polarity, an alternative Wnt pathway. Here, we review the progress made in understanding these mysterious proteins and, in particular, we focus on their function as Wnt receptors.
Additional Information
Copyright © 2008 Elsevier. Available online 9 October 2008. P.W.S. is an investigator with the HHMI. J.L.G. was supported by the Thomas Hunt Morgan Fellowship for graduate study toward the Doctor of Philosophy degree in Biology at the California Institute of Technology. S.G.K. was supported by NIH training grant GM07616.Attached Files
Accepted Version - nihms-737512.pdf
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Additional details
- PMCID
- PMC4672995
- Eprint ID
- 12526
- Resolver ID
- CaltechAUTHORS:GREtcb08
- Howard Hughes Medical Institute (HHMI)
- Thomas Hunt Morgan Fellowship, Caltech
- NIH
- GM07616
- Created
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2008-12-16Created from EPrint's datestamp field
- Updated
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2021-11-08Created from EPrint's last_modified field