Developmental changes in estrogen-sensitive neurons in the forebrain of the zebra finch
- Creators
- Gahr, Manfred
- Konishi, Masakazu
Abstract
The brain areas for the control of song are sexually dimorphic in the zebra finch (Poephila guttata). Implantation of estrogen in young females within the first 40 days after hatching masculinizes their brain song areas. Monoclonal antibody (H222Spγ) against the estrogen receptor was used for the localization of estrogen-target cells in the brain. The nucleus hyperstriatum ventrale, pars caudale, was the only song control area that contained cells with estrogen-receptor sites. The number of these cells varied during ontogeny and declined sharply after day 40. No other song areas contained estrogen-target cells despite their ability to undergo masculine differentiation under the influence of estrogen. Therefore, the action of estrogen on these nuclei must be indirect.
Additional Information
Copyright © 1988 by the National Academy of Sciences. Contributed by Masakazu Konishi, May 26, 1988. We thank E. Akutagawa for assistance, Drs. B. S. McEwen, M. J. Walters, and S. F. Volman for reading an early version of the manuscript, the Markey Charitable Trust for financial support through a grant to the Division of Biology, the German Academic Exchange Agency for a fellowship to M.G., and Abbott Laboratories for donation of the antibody. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.Attached Files
Published - GAHpnas88.pdf
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Additional details
- PMCID
- PMC282190
- Eprint ID
- 1609
- Resolver ID
- CaltechAUTHORS:GAHpnas88.861
- Lucille P. Markey Charitable Trust
- Deutscher Akademischer Austauschdienst (DAAD)
- Created
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2006-02-02Created from EPrint's datestamp field
- Updated
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2022-10-05Created from EPrint's last_modified field