Published March 1, 1965
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Journal Article
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Cell-transforming ability of a temperature-sensitive mutant of polyoma virus
- Creators
- Fried, Michael
Chicago
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Abstract
Conditional lethal mutants have been shown to be extremely useful in the study of the physiology of viral reproduction and maturation.(1, 2) Since such mutants are distributed over most of the genetic map,(1, 2) they could prove to be valuable in the study of tumor viruses. They may be used to "tag" almost all of the viral genes, a property of obvious physiological and genetical implication; they can also be useful for studying the mechanisms by which these viruses transform normal cells into cancer cells.
Additional Information
© 1965 by the National Academy of Sciences. Communicated by Renato Dulbecco, January 18, 1965. The author wishes to thank Professor Renato Dulbecco and Dr. Marguerite Vogt for their advice, encouragement, and stimulation in the pursuit of this work, and also for their many helpful discussions and suggestions in the preparation of this paper. This work was supported in part by a grant (112) from The Nutrition Foundation, and was aided by a USPHS graduate training grant (5T1 GM86).Files
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- CaltechAUTHORS:FRIpnas65
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