Published July 1, 1980
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Uniparental propagation of mitochondrial DNA in mouse-human cell hybrids
Abstract
The retention of the two parental mitochondrial DNAs has been investigated in a large number of mouse-human cell hybrids segregating either mouse or human chromosomes, by using a highly sensitive and specific method for detection of the DNA; the results have been correlated with the karyotype and isozyme marker pattern in the same hybrid lines. In all the hybrids examined, a consistent pattern was observed for the type of mitochondrial DNA retained: the mitochondrial DNA of the parent whose chromosomes were segregated from the nucleus was undetectable or present in marginal amounts. This was true also of hybrids containing a complete set of the segregating chromosomes in the total or a large fraction of the cell population.
Additional Information
Copyright © 1980 by the National Academy of Sciences. Communicated by Hilary Koprowski, March 13, 1980. This work was supported by Research Grant PCM-7718037 from the National Science Foundation and a Junior Fellowship of the American Cancer Society, California Division (to L.D.), and by grants from the National Institutes of Health and the National Foundation-March of Dimes. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U. S. C. §1734 solely to indicate this fact.Files
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