Protein kinase C inhibitors prevent induction and continued expression of cell memory in Hermissenda type B photoreceptors
- Creators
- Farley, Joseph
-
Schuman, Erin
Abstract
Injections of cAMP-dependent, Ca2+/calmodulin-dependent, or Ca2+/phospholipid-dependent protein kinases into Hermissenda crassicornis type B photoreceptors are sufficient to induce many of the changes in B-cell excitability produced by associative conditioning. We report that inhibitors of Ca2+/phospholipid-dependent protein kinases, but not inhibitors of cyclic nucleotide- or Ca2+/calmodulin-dependent protein kinases, prevent the induction as well as continued expression of learning-produced changes in type-B-cell excitability: reductions of voltage-dependent and Ca2+-activated K+ currents. Our results represent a direct demonstration of long-term (days) experientially induced modulation of ion-channel activity that is dependent upon persistent kinase activity.
Additional Information
© 1991 by the National Academy of Sciences. Communicated by James L. McGaugh, October 29, 1990. We thank Drs. Sidney Auerbach and Alexandra Newton for providing purified PKC. We thank Dr. Newton for useful discussions and critical reading of the manuscript. This work was supported in part by National Institutes of Health Grant NS26106. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.Attached Files
Published - FARpnas91.pdf
Files
| Name | Size | Download all |
|---|---|---|
|
md5:c7759e3420200b5d0278b0db2afa8871
|
1.3 MB | Preview Download |
Additional details
- PMCID
- PMC51157
- Eprint ID
- 1591
- Resolver ID
- CaltechAUTHORS:FARpnas91
- NIH
- NS26106
- Created
-
2006-02-01Created from EPrint's datestamp field
- Updated
-
2021-11-08Created from EPrint's last_modified field