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Published July 10, 1982 | public
Journal Article Open

The nucleotide sequence of a human immnnoglobulin C-gamma-1 gene

Abstract

We report the nucleotide sequence of a gene encoding the constant region of a human immnnoglobulin γ1 heavy chain (Cγ1). A comparison of this sequence with those of the Cγ2 and Cγ4 genes reveals that these three human Cγ genes share considerable homology in both coding and noncoding regions. The nucleotide sequence differences indicate that these genes diverged from one another approximately 6–8 million years ago. An examination of hinge exons shows that these coding regions have evolved more rapidly than any other areas of the Cγ genes in terms of both base substitution and deletion–insertion events. Coding sequence diversity also is observed in areas of CH domains which border the hinge.

Additional Information

Copyright © 1982 Oxford University Press. Received 12 April 1982; Revised and Accepted 2 June 1982. This work was supported by a grant from the National Institutes of Health and a National Research Service Award from the National Institute of General Medical Sciences to J.E. We thank Karyl Minard for excellent technical assistance and Stephanie Canada for the preparation of the manuscript.

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August 22, 2023
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October 13, 2023