Published October 1, 1949 | public
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The Role of Organic Peroxides in the Induction of Mutations

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Abstract

The discovery by Wyss, Stone, and Clark' that bacteria grown on a substrate recently exposed to ultra-violet light are subject to high mutation rates shows clearly that some meta-stable chemical substance, probably of no great complexity, is an intermediate in at least a part of the mutagenic action of ultra-violet light. It was supposed that hydrogen peroxide might be responsible for these results, but subsequent work has shown that this cannot be the whole explanation. [2] However, organic peroxides are known to be formed by the action of ultra-violet light on many compounds and such peroxides might very well be the intermediate agents producing the substrate irradiation effect.

Additional Information

Copyright © 1949 by the National Academy of Sciences Communicated by G. W. Beadle, August 15, 1949 This investigation was supported in part by a research grant from Merck and Co. [F.H.D. was a] DuPont Predoctoral Fellow in Chemistry 1948-1949. The authors wish to thank Professor Norman H. Horowitz for valuable assistance and advice.

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