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Published May 1975 | Published
Journal Article Open

Effects of discrete nuclear u.v-microbeam irradiation on herpes virus and SV40 infection

Abstract

The requirement for a nucleolus in the expression of structural genes of nuclear viruses was examined by means of experiments in which the nucleolus or other parts of the nucleus was inactivated by a microbean of unltraviolet light. These experiments showed that the expression of such genes is not dependent on cucleolar function. This conclusion is discussed in the light of previous experiments in which similar inactiviation of nucleolus was shown to prevent the expression of cellular structural genes.

Additional Information

Copyright © 1975 by Company of Biologists. (Received 15 October 1974) This work was done while I.I.D. held a Grocers' Company Research Fellowship at New College, Oxford. We thank Professor Henry Harris for advice and Mrs J.P. McAvoy for technical assistance.

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