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Published December 1974 | Published
Journal Article Open

Class of {varphi}X174 Mutants Relatively Deficient in Synthesis of Viral RNA

Abstract

Nonpermissive cells infected with {varphi}X174 gene D amber mutants synthesized some sixfold less viral RNA than permissive cells. The decrease was unaffected by increasing the multiplicity of infection and was a consequence of an overall decrease in all viral RNA species. It is suggested that the gene D product may function in replicative form DNA unwinding to expose the template for transcription.

Additional Information

© 1975 American Society for Microbiology. Received for publication 17 June 1974. This research was supported in part by Public Health Service grant GM13554 from the National Institute of General Medical Sciences.

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August 22, 2023
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