Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published February 2006 | Published
Journal Article Open

Formation and removal of alkylthiolate self-assembled monolayers on gold in aqueous solutions

An error occurred while generating the citation.

Abstract

We report the development of novel reagents and approaches for generating recyclable biosensors. The use of aqueous media for the formation of protein binding alkylthiolate monolayers on Au surfaces results in accelerated alkylthiolate monolayer formation and improvement in monolayer integrity as visualized by fluorescence microscopy and CV techniques. We have also developed an electrocleaning protocol that is compatible with microfluidics devices, and this technique serves as an on-chip method for cleaning Au substrates both before and after monolayer formation. The techniques for the formation and dissociation of biotinylated SAMs from aqueous solvents reported here may be applied towards the development of Au-based sensor devices and microfluidics chips in the future. A potential use of these devices includes the specific capture and triggered release of target cells, proteins, or small molecules from liquid samples.

Additional Information

© The Royal Society of Chemistry 2006 Received 26th July 2005, Accepted 6th December 2005. First published on the web 3rd January 2006 This research was funded under DARPA grant MLR.00018-3-AFOSR.000019 and RDL.NASA.000143. The authors thank Blake Axelrod, Jessica Arlett, and Melaku Muluneh for their assistance in materials fabrication. C.A.C. thanks John Keith and Brad Cenko for helpful discussions.

Attached Files

Published - CANloac06.pdf

Files

CANloac06diag.gif
Files (336.8 kB)
Name Size Download all
md5:f748a936d471ead6798f16c5c7bcadb9
11.3 kB Preview Download
md5:d2b52c4ad044b0a747261b943bd322c2
307.4 kB Preview Download
md5:6b62609e629bf7cff8443a9b4bb0b169
2.8 kB Preview Download
md5:d76365d6a8342820a13cedfd50ab2cac
15.3 kB Preview Download

Additional details

Created:
August 22, 2023
Modified:
October 16, 2023