The degradation of alpha-aminoadipic acid in guinea pig liver homogenate

Creators: Borsook, Henry; Deasy, Clara L.; Haagen-Smit, A. J.; Keighley, Geoffrey; Lowy, Peter H.

Abstract

In continuation of our study of the metabolism of L-lysine, α-aminoadipic acid, which is formed from lysine in guinea pig liver homogenate (1), was synthesized with C14 in the ε-position. The metabolism of the latter compound was followed by search for the radioactive tracer among the probable metabolic products. Two have been identified, α-ketoadipic and glutaric acids.

Additional Information

© 1948 American Society of Biological Chemists. Received for publication, June 21, 1948. The elementary analyses were carried out by Dr. G. Oppenheimer. The authors were assisted in this work by A.A. Dvorsky, D. Eggarter, H. E. Jeffery, and A. Tollestrup. This work is part of that done under contract with the Office of Naval Research, United States Navy Department. It was reported at the meeting of the American Society of Biological Chemists, March 15-19, 1948. The C14 used in this investigation was supplied by the Monsanto Chemical Company, Clinton Laboratories, Oak Ridge, Tennessee, and obtained on allocation from the United States Atomic Energy Commission.

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