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Published December 31, 2003 | Published + Supplemental Material + Erratum
Journal Article Open

Behavior of Complex Knots in Single DNA Molecules

Abstract

We used optical tweezers to tie individual DNA molecules in knots. Although these knots become highly localized under tension, they remain surprisingly mobile and undergo thermal diffusion with classical random walk statistics. The diffusion constants of knots with different complexities correlate with theoretical calculations of knot sizes. We show that this correlation can be explained by a simple hydrodynamical model of "self-reptation" of the knot along a polymer.

Additional Information

©2003 The American Physical Society (Received 1 August 2003; published 31 December 2003) We thank D.E. Smith, P. Pieranski, M. Wang, and J. Su for helpful discussion, and J.-C. Meiners, K. Matthews, and A. Groisman for help with preliminary experiments. This work was funded in part by a grant from the Packard Foundation; X.R.B. thanks the Hertz Foundation for financial support. See Also: * Phys. Rev. Focus 12, story 25 * Erratum: Xiaoyan R. Bao et al. Phys. Rev. Lett. 95, 199901 (E) (2005)

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Published - BAOprl03.pdf

Supplemental Material - BAOprl03movie.mov

Supplemental Material - BAOprl03movie.mpg

Supplemental Material - BAOprl03readme.txt

Erratum - BAOprl03corr.pdf

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