Published July 15, 1965
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Journal Article
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Recognition of Ribosomal RNA sites in DNA, II. The Hela Cell System
Chicago
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Abstract
As reported in a preceding paper,[1] the analysis of the sedimentation behavior and base composition of the RNA recovered from hybrids between E. coli 16S and 238 RNA and homologous DNA, after RNase digestion of non-base-paired segments, has given results which suggest a regular and complete hydrogen bonding of the hybridized RNA with specific sites in DNA. A similar analysis has now been applied to the investigation of ribosomal RNA sites in HeLa and other human DNA's and has made it possible to resolve the ambiguities in specificity pattern and base composition presented by the raw hybridization data, and to identify among the RNA-DNA complexes a fraction which appears to involve specific sites in DNA.
Additional Information
Copyright © 1965 by National Academy of Sciences Communicated by Renato Dulbecco, May 5, 1965. These investigations were supported by a research grant from the National Institutes of Health (GM-11726). The help of Barbara Attardi in some of the experiments described here and in the preparation of the manuscript is gratefuly acknowledged. We thank LaVerne Wenzel and Sandra Kiddy for their capable assistance.Files
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