Synthesis of oligosaccharide libraries for systematic explorations of heparan sulfate sequence space

Creators: Sorum, Alexander W.; Hsieh-Wilson, Linda C.

Abstract

Challenges in the synthesis of heparan sulfate (HS) glycosaminoglycans have limited access to defined HS oligosaccharides bearing a diverse array of sulfation sequences. A concise, divergent synthetic approach now provides a library of 64 HS tetrasaccharides displaying a comprehensive set of sulfation sequences, offering insight into the elusive sulfation code of glycosaminoglycans.

Additional Information

© 2023 Springer Nature. This is a summary of: Wang, L. et al. Efficient platform for synthesizing comprehensive heparan sulfate oligosaccharide libraries for decoding glycosaminoglycan–protein interactions Nat. Chem. https://doi.org/10.1038/s41557-023-01248-4 (2023).

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Resource type: Journal Article
Publisher: Nature Publishing Group
Published in: Nature Chemistry, 15(8), 1062-1063, ISSN: 1755-4330.

Created:: August 22, 2023
Modified:: October 23, 2023