A stretchable wireless wearable bioelectronic system for multiplexed monitoring and combination treatment of infected chronic wounds
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1.
California Institute of Technology
Abstract
Chronic nonhealing wounds are one of the major and rapidly growing clinical complications all over the world. Current therapies frequently require emergent surgical interventions, while abuse and misapplication of therapeutic drugs often lead to an increased morbidity and mortality rate. Here, we introduce a wearable bioelectronic system that wirelessly and continuously monitors the physiological conditions of the wound bed via a custom-developed multiplexed multimodal electrochemical biosensor array and performs noninvasive combination therapy through controlled anti-inflammatory antimicrobial treatment and electrically stimulated tissue regeneration. The wearable patch is fully biocompatible, mechanically flexible, stretchable, and can conformally adhere to the skin wound throughout the entire healing process. Real-time metabolic and inflammatory monitoring in a series of preclinical in vivo experiments showed high accuracy and electrochemical stability of the wearable patch for multiplexed spatial and temporal wound biomarker analysis. The combination therapy enabled substantially accelerated cutaneous chronic wound healing in a rodent model.
Additional Information
© 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/. We gratefully acknowledge critical support and infrastructure provided for this work by the Kavli Nanoscience Institute and the Biological Imaging Facility at the Beckman Institute at Caltech. This work was supported by National Institutes of Health grant R01HL155815 (W.G.), National Institutes of Health grant R21DK13266 (W.G.), National Science Foundation grant 2145802 (W.G.), Office of Naval Research grant N00014-21-1-2483 (W.G.), Office of Naval Research grant N00014-21-1-2845 (W.G.), Heritage Medical Research Institute at the California Institute of Technology (Caltech) (W.G.), Donna and Benjamin M. Rosen Bioengineering Center at Caltech (W.G.), Rothenberg Innovation Initiative at Caltech (W.G.), Sloan Research Fellowship. Author contributions: Conceptualization: W.G. and E.S.S. Supervision: W.G. Methodology: W.G., E.S.S., and C.X. Investigation: E.S.S., C.X., C.W., Y.S., J.M., J.T., S.A.S., J.L., J.L.B., and D.G.A. Funding acquisition: W.G. Writing—original draft: W.G., E.S.S., and C.X. Writing—review and editing: C.W., Y.S., J.M., J.T., S.A.S., J.L., J.L.B., and D.G.A. Competing interests: E.S.S. and W.G. are inventors of a patent application through California Institute of Technology describing the system and technology under the U.S. provisional patent application no. 17/993,743 (filed on 23 November 2022). The authors declare that they have no other competing interests.Attached Files
Published - sciadv.adf7388.pdf
Supplemental Material - sciadv.adf7388_movie_s1.zip
Supplemental Material - sciadv.adf7388_sm.pdf
Files
Additional details
- PMCID
- PMC10038347
- Eprint ID
- 120488
- Resolver ID
- CaltechAUTHORS:20230328-625234000.1
- R01HL155815
- NIH
- R21DK13266
- NIH
- ECCS-2145802
- NSF
- N00014-21-1-2483
- Office of Naval Research (ONR)
- N00014-21-1-2845
- Office of Naval Research (ONR)
- Heritage Medical Research Institute
- Donna and Benjamin M. Rosen Bioengineering Center
- Rothenberg Innovation Initiative (RI2)
- Alfred P. Sloan Foundation
- Created
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2023-03-30Created from EPrint's datestamp field
- Updated
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2023-03-30Created from EPrint's last_modified field
- Caltech groups
- Kavli Nanoscience Institute, Heritage Medical Research Institute, Rosen Bioengineering Center