Pollen Typhae-Based Magnetic-Powered Microrobots toward Acute Gastric Bleeding Treatment
Abstract
Traditional Chinese herbal medicine (TCHM) is the naturally available pharmaceutical with millennia of evolution from ancient China, capable of a superior therapeutic index and minimized unwanted effects on the human body. This work presents a therapeutic microrobotic platform based on pollen typhae (PT), a typical type of TCHM, fabricated by coating porous PT microspheres with Fe₃O₄ nanoparticles (PT robots) via electrostatic adsorption. The PT robots exhibit effective and controllable motion in various biological media upon external magnetic control and, meanwhile, preserve the inherent hemostasis property of PT. The blood clotting capacity of PT robots is attributed to their stimulation of the endogenous blood coagulation pathway and platelets with increased counts, which could be further improved by their effective magnetic propulsion. The remote magnetic control also allows the manipulation of PT robots in mice stomach, inducing enhanced binding and prolonged retention of PT robots in stomach mucosa. Moreover, PT robots upon magnetic control show an enhanced hemostatic effect in treating the mice bearing acute gastric bleeding compared with other passive groups. This work offers a facile and feasible route to integrate TCHM with manmade micromachines possessing the innate curative features of TCHM. Such a design expanded the versatility of microrobots and can be generalized to vast types of TCHM for broader biomedical applications.
Additional Information
© 2022 American Chemical Society. Received 21 June 2022. Accepted 2 August 2022. Published online 15 August 2022. This work was supported by the Guangdong Special Support Program of Youth Talent with Scientific and Technological Innovation, National Key Research and Development Program of China (2017YFA0105900), National Natural Science Foundation Fund of China (81922046, 61931024, and 32101133), Special Funds for Strategic Emerging Industries Development in Shenzhen (20180309163446298), Shenzhen Science and Technology Program (grant number JCYJ20210324125006019), and Shenzhen Key Laboratory Program (ZDSYS20190902092857146). The authors declare no competing financial interest.Attached Files
Supplemental Material - mt2c00565_si_001.pdf
Supplemental Material - mt2c00565_si_002.mov
Supplemental Material - mt2c00565_si_003.mov
Supplemental Material - mt2c00565_si_004.mov
Supplemental Material - mt2c00565_si_005.mov
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Additional details
- Eprint ID
- 116300
- DOI
- 10.1021/acsabm.2c00565
- Resolver ID
- CaltechAUTHORS:20220816-201464000
- Guangdong Science and Technology Department
- 2017YFA0105900
- Ministry of Science and Technology of the People's Republic of China
- 81922046
- National Natural Science Foundation of China
- 61931024
- National Natural Science Foundation of China
- 32101133
- National Natural Science Foundation of China
- 20180309163446298
- Development and Reform Commission of Shenzhen Municipality
- JCYJ20210324125006019
- Science, Technology and Innovation Commission of Shenzhen Municipality
- ZDSYS20190902092857146
- Science, Technology and Innovation Commission of Shenzhen Municipality
- Created
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2022-08-16Created from EPrint's datestamp field
- Updated
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2022-10-06Created from EPrint's last_modified field