Symbiosis-driven development in an early branching metazoan
- Creators
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Ohdera, Aki H.
- Darymple, Justin
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Avila-Magaña, Viridiana
- Sharp, Victoria
- Watson, Kelly
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McCauley, Mark
- Steinworth, Bailey
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Diaz-Almeyda, Erika M.
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Kitchen, Sheila A.
- Poole, Angela Z.
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Bellantuono, Anthony
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Haridas, Sajeet
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Grigoriev, Igor V.
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Goentoro, Lea
- Vallen, Elizabeth
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Baker, David M.
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LaJeunesse, Todd C.
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Loesgen, Sandra
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Martindale, Mark Q.
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DeGennaro, Matthew
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Fitt, William K.
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Medina, Mónica
Abstract
Microbes can initiate developmental gene regulatory cascades in animals. The molecular mechanisms underlying microbe-induced animal development and the evolutionary steps to integrate microbial signals into regulatory programs remain poorly understood. In the upside-down jellyfish Cassiopea xamachana, a dinoflagellate endosymbiont initiates the life stage transition from the sessile polyp to the sexual medusa. We found that metabolic products derived from symbiont carotenoids may be important to initiate C. xamachana development, in addition to expression of conserved genes involved in medusa development of non-symbiotic jellyfish. We also revealed the transcription factor COUP is expressed during metamorphosis, potentially as a co-regulator of nuclear receptor RXR. These data suggest relatively few steps may be necessary to integrate symbiont signals into gene regulatory networks and cements the role of the symbiont as a key trigger for life history transition in C. xamachana.
Additional Information
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license. The work conducted by the U.S. Department of Energy Joint Genome Institute, a DOE Office of Science User Facility, is supported by the Office of Science of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. The authors have declared no competing interest.Attached Files
Submitted - 2022.07.21.500558v1.full.pdf
Supplemental Material - media-1.pdf
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Additional details
- Eprint ID
- 115809
- Resolver ID
- CaltechAUTHORS:20220725-414384000
- Department of Energy (DOE)
- DE-AC02-05CH11231
- Created
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2022-07-27Created from EPrint's datestamp field
- Updated
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2022-07-27Created from EPrint's last_modified field
- Caltech groups
- Division of Biology and Biological Engineering