The Intimate Connection Between Lipids and Hedgehog Signaling

Creators: Nguyen, Thi D.; Truong, Melissa E.; Reiter, Jeremy F.

Abstract

Hedgehog (HH) signaling is an intercellular communication pathway involved in directing the development and homeostasis of metazoans. HH signaling depends on lipids that covalently modify HH proteins and participate in signal transduction downstream. In many animals, the HH pathway requires the primary cilium, an organelle with a specialized protein and lipid composition. Here, we review the intimate connection between HH signaling and lipids. We highlight how lipids in the primary cilium can create a specialized microenvironment to facilitate signaling, and how HH and components of the HH signal transduction pathway use lipids to communicate between cells.

Additional Information

© 2022 Nguyen, Truong and Reiter. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Received: 15 February 2022; Accepted: 13 May 2022; Published: 09 June 2022. This work was funded by NIH R01GM095941, R01AR054396, and R01HD089918 to JR. Author Contributions. TN, MT and JR wrote and edited the manuscript. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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