Published June 2, 2022
| Published
Journal Article
Open
Loss of famh-136/ FAM136A results in minor locomotion and behavioral changes in Caenorhabditis elegans
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Abstract
The human gene FAM136A (family with sequence similarity 136 member A) has been associated with familial Meniere's disease (MD) (Requena et al., 2015), a chronic disorder of the inner ear (Nakashima et al., 2016). There is also a suggestion that the expression of the gene could be associated with lung cancer prognosis (Zhao et al., 2020). FAM136A is evolutionary conserved, with orthologs identified in various metazoan species (Alliance of Genome Resources, 2022). However, with the exception of some expression data and omics level analysis (Alliance of Genome Resources, 2022; Stuckenholz et al., 2009), very little is known about FAM136A.
Additional Information
© 2022 by the authors. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Received: 3/26/2022. Revision Received: 4/23/2022. Accepted: 5/30/2022. Published: 6/2/2022. We thank Tsui-Fen Chou for providing Cas9 protein and Wan-Rong Wong for experimental and technical advice. We would also like to thank all members of the Sternberg lab for experimental support and discussions. This work was supported by NIH grants R24OD023041 and R01 HD086596 (PWS). Funding: NIH grants R24OD023041 and R01 HD086596 (PWS). Author Contributions. Chieh-Hsiang Tan: Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing - original draft, Writing - review & editing Heenam Park: Investigation, Resources, Writing - review & editing Paul W. Sternberg: Conceptualization, Funding acquisition, Supervision, Writing - review & editingAttached Files
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Additional details
- PMCID
- PMC9163966
- Eprint ID
- 115051
- Resolver ID
- CaltechAUTHORS:20220607-425206000
- NIH
- R24OD023041
- NIH
- R01 HD086596
- Created
-
2022-06-07Created from EPrint's datestamp field
- Updated
-
2023-06-01Created from EPrint's last_modified field
- Caltech groups
- Division of Biology and Biological Engineering (BBE)