Convergent pathways of the gut microbiota–brain axis and neurodegenerative disorders
Abstract
Recent research has been uncovering the role of the gut microbiota for brain health and disease. These studies highlight the role of gut microbiota on regulating brain function and behavior through immune, metabolic, and neuronal pathways. In this review we provide an overview of the gut microbiota axis pathways to lay the groundwork for upcoming sessions on the links between the gut microbiota and neurogenerative disorders. We also discuss how the gut microbiota may act as an intermediate factor between the host and the environment to mediate disease onset and neuropathology. Based on the current literature, we further examine the potential for different microbiota-based therapeutic strategies to prevent, to modify, or to halt the progress of neurodegeneration.
Additional Information
© The Author(s) 2022. Published by Oxford University Press and Sixth Affiliated Hospital of Sun Yat-sen University This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. Received: 23 January 2022. Revision received: 22 March 2022. Accepted: 01 April 2022. Published: 16 May 2022. C.G. is a Hereditary Disease Foundation (HDF) Fellow. L.H.M. is a postdoctoral scholar at Caltech and recipient of the American Parkinson's Disease Association postdoctoral fellowship. Carolina Gubert and Juciano Gasparotto contributed equally to this work. Authors' Contributions. All the authors contributed substantially to discussions of the article content and to the writing. L.H.M. conceived of the idea and coordinated the study. All authors read and approved the final manuscript. Conflict of Interest: None declared.Attached Files
Accepted Version - goac017.pdf
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Additional details
- PMCID
- PMC9109005
- Eprint ID
- 114810
- Resolver ID
- CaltechAUTHORS:20220519-375143000
- Hereditary Disease Foundation
- American Parkinson's Disease Association
- Created
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2022-05-19Created from EPrint's datestamp field
- Updated
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2023-07-06Created from EPrint's last_modified field