Published November 15, 2009
| public
Journal Article
Identification of the amino acid-AZT-phosphoramidase by affinity T7 phage display selection
Abstract
A CEM cell cDNA T7 phage display library was prepared and used to screen for activating enzymes of phosphoramidate prodrugs of AZT monophosphate. Although, inefficient compared to ribonucleotide based phosphoramidates, hHint 1 was identified as the likely intracellular pronucleotide activating enzyme.
Additional Information
© 2009 Published by Elsevier. Received 25 July 2009, Revised 17 September 2009, Accepted 17 September 2009, Available online 22 September 2009. This work was partially supported by Grant CA-61909 and the University of Minnesota Graduate School (C.R.W).Additional details
- Eprint ID
- 114057
- DOI
- 10.1016/j.bmcl.2009.09.067
- Resolver ID
- CaltechAUTHORS:20220323-565985000
- University of Minnesota
- Created
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2022-03-24Created from EPrint's datestamp field
- Updated
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2022-03-24Created from EPrint's last_modified field