Published July 2021
| Published
Journal Article
Open
Innovation by evolution: bringing new chemistry to life
- Creators
- Arnold, Frances
Abstract
Not satisfied with biology's vast catalyst repertoire, we create new enzyme catalysts and expand the chemistry of life. We use the most powerful biological design process, evolution, to optimize existing enzymes and invent new ones, thereby circumventing our profound ignorance of how sequence encodes function. With a little insight from chemistry, we can generate enzymes for transformations that are unknown in biology. These new-to-nature enzymes increase the scope of molecules and materials we can build using synthetic biology and move us closer to a sustainable world where human-invented chemistry will be genetically encoded.
Additional Information
© 2021 International Union of Crystallography.Attached Files
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Additional details
- Eprint ID
- 112773
- Resolver ID
- CaltechAUTHORS:20220107-161550932
- Created
-
2022-01-09Created from EPrint's datestamp field
- Updated
-
2022-01-09Created from EPrint's last_modified field
- Caltech groups
- Division of Biology and Biological Engineering