Letting the little light of mind shine: Advances and future directions in neurochemical detection
Abstract
Synaptic transmission via neurochemical release is the fundamental process that integrates and relays encoded information in the brain to regulate physiological function, cognition, and emotion. To unravel the biochemical, biophysical, and computational mechanisms of signal processing, one needs to precisely measure the neurochemical release dynamics with molecular and cell-type specificity and high resolution. Here we reviewed the development of analytical, electrochemical, and fluorescence imaging approaches to detect neurotransmitter and neuromodulator release. We discussed the advantages and practicality in implementation of each technology for ease-of-use, flexibility for multimodal studies, and challenges for future optimization. We hope this review will provide a versatile guide for tool engineering and applications for recording neurochemical release.
Additional Information
© 2021 Published by Elsevier. Received 28 November 2021, Accepted 29 November 2021, Available online 30 November 2021. We would like to thank our funding sources for supporting this work, including NIH5T32GM099608-10 (N.T.), NIAR01AG054649-05(Y.H.), NIH U01NS099726 (A.H., M.R.), NIHU01NS115579, U01NS120820 (L.T.).Attached Files
Accepted Version - nihms-1789678.pdf
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Additional details
- PMCID
- PMC9508992
- Eprint ID
- 112168
- DOI
- 10.1016/j.neures.2021.11.012
- Resolver ID
- CaltechAUTHORS:20211202-191325802
- NIH Predoctoral Fellowship
- 5T32GM099608-10
- NIH
- R01AG054649-05
- NIH
- U01NS099726
- NIH
- U01NS115579
- NIH
- U01NS120820
- Created
-
2021-12-03Created from EPrint's datestamp field
- Updated
-
2023-07-06Created from EPrint's last_modified field
- Caltech groups
- Division of Biology and Biological Engineering