Published September 29, 2021
| Submitted + Supplemental Material
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How to model DNA replication in stochastic models of synthetic gene circuits (and why)
- Creators
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Clamons, Samuel E.
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Murray, Richard M.
Abstract
Biocircuit modeling sometimes requires explicit tracking of a self-replicating DNA species. The most obvious, straightforward way to model a replicating DNA is structurally unstable and leads to pathological model behavior. We describe a simple, stable replication mechanism with good model behavior and show how to derive it from a mechanistic model of ColE1 replication.
Additional Information
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license. This version posted September 27, 2021. The authors thank John Marken and Andrew Halleran for insightful discussions and thoughtful editing. The authors have declared no competing interest.Attached Files
Submitted - 2021.09.26.461880v1.full.pdf
Supplemental Material - media-1.zip
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media-1.zip
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Additional details
- Eprint ID
- 111092
- Resolver ID
- CaltechAUTHORS:20210929-174530596
- Created
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2021-09-29Created from EPrint's datestamp field
- Updated
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2021-11-16Created from EPrint's last_modified field
- Caltech groups
- Division of Biology and Biological Engineering