Can excitatory neuromodulation change distorted perception of one's appearance?
Abstract
Body dysmorphic disorder (BDD) is marked by preoccupation with misperceived appearance flaws. Previous functional magnetic resonance imaging (fMRI) studies have found reduced neural activity and connectivity of visual areas specialized for global/holistic visual processing in BDD [[1], [2], [3]], suggesting that aberrant dorsal visual system functioning might contribute to distorted perception. In this proof-of-concept study we tested if intermittent theta-burst stimulation (iTBS), a form of excitatory repetitive transcranial magnetic stimulation (rTMS), would enhance dorsal visual system utilization as quantified through dynamic effective connectivity (DEC) modeling [4]. This is a single-session study with the application of iTBS and an fMRI scan immediately afterwards (within 15 min after the stimulation). We hypothesized that those undergoing active iTBS would show enhanced connectivity in dorsal visual areas responsible for global/holistic visual processing compared with sham.
Additional Information
© 2021 Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Received 1 July 2021, Revised 20 July 2021, Accepted 22 July 2021, Available online 30 July 2021. This study was supported by the National Institute of Mental Health (R21MH110865 to JDF, R01MH121520 to JDF), the NIH National Center for Advancing Translational Science (NCATS) UCLA CTSI (UL1TR001881 to JDF), and the Nathan Cumming Foundation (JDF). Author contributions: WW, MSL, and JPD were responsible for data analysis and paper writing. RD, RT, and AL contributed to the study design. JDF was responsible for clinical assessment, experimental design, and paper writing. All authors read and approved the submitted manuscript. The authors declare no conflicts of interest.Attached Files
Published - 1-s2.0-S1935861X21001480-main_pub.pdf
Supplemental Material - 1-s2.0-S1935861X21001480-mmc1.docx
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Additional details
- Eprint ID
- 110677
- Resolver ID
- CaltechAUTHORS:20210831-222504574
- R21MH110865
- NIH
- R01MH121520
- NIH
- UL1TR001881
- NIH
- Nathan Cumming Foundation
- Created
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2021-08-31Created from EPrint's datestamp field
- Updated
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2021-11-16Created from EPrint's last_modified field