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Published October 2021 | Supplemental Material
Journal Article Open

Structural brain correlates in major depression, anxiety disorders and post-traumatic stress disorder: A voxel-based morphometry meta-analysis

Abstract

The high comorbidity of Major Depressive Disorder (MDD), Anxiety Disorders (ANX), and Posttraumatic Stress Disorder (PTSD) has hindered the study of their structural neural correlates. The authors analyzed specific and common grey matter volume (GMV) characteristics by comparing them with healthy controls (HC). The meta-analysis of voxel-based morphometry (VBM) studies showed unique GMV diminutions for each disorder (p < 0.05, corrected) and less robust smaller GMV across diagnostics (p < 0.01, uncorrected). Pairwise comparison between the disorders showed GMV differences in MDD versus ANX and in ANX versus PTSD. These results endorse the hypothesis that unique clinical features characterizing MDD, ANX, and PTSD are also reflected by disorder specific GMV correlates.

Additional Information

© 2021 Elsevier Ltd. Received 25 January 2021, Revised 6 June 2021, Accepted 5 July 2021, Available online 10 July 2021. PK was supported by a fellowship from the Adrian and Simone Frutiger Foundation. TW was supported by an NIHR PhD studentship and a Sir Henry Wellcome postdoctoral fellowship from the Wellcome Trust. EV was supported by a Río Hortega fellowship, provided by the Carlos III Health Institute (ISCIII), Spain (CM15/000839). NC has received research scholarships from Recercaixa, the Spanish Ministry of Health, the Ministry of Science and Innovation (CIBERSAM) and the Strategic Plan for Health Research and Innovation (PERIS)2016-2020.

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Created:
August 22, 2023
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October 23, 2023