Published May 13, 2021
| Published
Journal Article
Open
Changing the Cortical Conductor's Tempo: Neuromodulation of the Claustrum
Abstract
The claustrum is a thin sheet of neurons that is densely connected to many cortical regions and has been implicated in numerous high-order brain functions. Such brain functions arise from brain states that are influenced by neuromodulatory pathways from the cholinergic basal forebrain, dopaminergic substantia nigra and ventral tegmental area, and serotonergic raphe. Recent revelations that the claustrum receives dense input from these structures have inspired investigation of state-dependent control of the claustrum. Here, we review neuromodulation in the claustrum—from anatomical connectivity to behavioral manipulations—to inform future analyses of claustral function.
Additional Information
© 2021 Wong, Nair and Augustine. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Received: 25 January 2021; Accepted: 29 March 2021; Published: 13 May 2021. We thank M. Graf, Z. Chia, G. X. Ham, and M. Zhang for insightful discussions and comments on our article. We acknowledge the Allen Brain Institute's open access Mouse Connectivity database (http://connectivity.brain-map.org/) for their anatomical connectivity data. Author Contributions. All authors contributed to the article and approved the submitted version. This work was supported by the Singapore Ministry of Education under its Singapore Ministry of Education Academic Research Fund Tier 3 (MOE2017-T3-1-002). The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.Attached Files
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Additional details
- PMCID
- PMC8155375
- Eprint ID
- 109423
- Resolver ID
- CaltechAUTHORS:20210607-115056404
- MOE2017-T3-1-002
- Ministry of Education (Singapore)
- Created
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2021-06-10Created from EPrint's datestamp field
- Updated
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2021-11-16Created from EPrint's last_modified field