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Published June 2021 | Accepted Version
Journal Article Open

Schwann cell precursors: Where they come from and where they go

Abstract

Schwann cell precursors (SCPs) are a transient population in the embryo, closely associated with nerves along which they migrate into the periphery of the body. Long considered to be progenitors that only form Schwann cells—the myelinating cells of nerves, current evidence suggests that SCPs have much broader developmental potential. Indeed, different cell marking techniques employed over the past 20 years have identified multiple novel SCP derivatives throughout the body. It is now clear that SCPs represent a multipotent progenitor population, which also display a level of plasticity in response to injury. Moreover, they originate from multiple origins in the embryo and may reflect several distinct subpopulations in terms of molecular identity and fate. Here we review SCP origins, derivatives and plasticity in development, growth and repair.

Additional Information

© 2021 Elsevier. Received 28 February 2021, Revised 29 April 2021, Accepted 30 April 2021, Available online 3 May 2021. This work was supported by grants from the National Institutes of Health (R01DE027568 and R35NS111564). CRediT authorship contribution statement. Tatiana Solovieva and Marianne Bronner wrote the manuscript. There are no competing interests.

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Created:
August 22, 2023
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December 22, 2023