Functionalization of Rh^(III)–Me Bonds: Use of "Capping Arene" Ligands to Facilitate Me–X Reductive Elimination
Abstract
We show how to improve the yield of MeX from CH₄ activation catalysts from 12% to 90% through the use of "capping arene" ligands. Four (FP)Rh^(III)(Me)(TFA)₂ {FP = "capping arene" ligands, including 8,8′-(1,2-phenylene)diquinoline (6-FP), 8,8′-(1,2-naphthalene)diquinoline (6-^(NP)FP), 1,2-bis(N-7-azaindolyl)benzene (5-FP), and 1,2-bis(N-7-azaindolyl)naphthalene (5-^(NP)FP)} complexes. These complexes and (dpe)Rh^(III)(Me)(TFA)₂ (dpe = 1,2-di-2-pyridylethane) were synthesized and tested for their performance in reductive elimination of MeX (X = TFA or halide). The FP ligands were used with the goal of blocking a coordination site to destabilize the Rh^(III) complexes and facilitate MeX reductive elimination. On the basis of single-crystal X-ray diffraction studies, the 6-FP and 6-^(NP)FP ligated Rh complexes have Rh–arene distances shorter than those of the 5-FP and 5-^(NP)FP Rh complexes; thus, it is expected that the Rh–arene interactions are weaker for the 5-FP complexes than for the 6-FP complexes. Consistent with our hypothesis, the 5-FP and 5-^(NP)FP Rh^(III) complexes demonstrate improved performance (from 12% to ∼60% yield) in the reductive elimination of MeX. The reductive elimination of MeX from (FP)Rh^(III)(Me)(TFA)₂ can be further improved by the use of chemical oxidants. For example, the addition of 2 equiv of AgOTf leads to 87(2)% yield of MeTFA and can be achieved in CD₃CN at 90 °C using (5-FP)Rh(Me)(TFA)₂.
Additional Information
© 2021 American Chemical Society. Received: April 8, 2021. The Gunnoe group acknowledges support from the U.S. National Science Foundation (1800173). C.B.M. and W.A.G. acknowledge support from the NSF (CBET-1805022). Single-crystal X-ray diffraction experiments were performed on a diffractometer at the University of Virginia funded by the NSF-MRI program (CHE-2018870). Accession Codes: CCDC 2046421–2046427, 2046429–2046432, and 2068537 contains the supplementary crystallographic data for this paper. Author Contributions: S.G. and J.C. contributed equally to this work. The authors declare no competing financial interest.Attached Files
Supplemental Material - om1c00223_si_001.pdf
Supplemental Material - om1c00223_si_002.xyz
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Additional details
- Alternative title
- Functionalization of RhIII–Me Bonds: Use of "Capping Arene" Ligands to Facilitate Me–X Reductive Elimination
- Eprint ID
- 109074
- Resolver ID
- CaltechAUTHORS:20210511-093624636
- CHE-1800173
- NSF
- CBET-1805022
- NSF
- CHE-2018870
- NSF
- Created
-
2021-05-11Created from EPrint's datestamp field
- Updated
-
2021-07-06Created from EPrint's last_modified field
- Other Numbering System Name
- WAG
- Other Numbering System Identifier
- 1423